The impact of early diastolic myocardial relaxation on the other parameters of diastolic function and association of tissue Doppler parameters of diastolic function with diabetes compensation and duration in type 2 diabetic patients.

Abstract:
This study assessed the impact of tissue Doppler derived myocardial early diastolic relaxation velocity [E(m)] on the other parameters of diastolic function (preload dependent transmitral earlydiastolic velocity [E], tissue Doppler derived myocardial late diastolic velocity [A(m)], preload dependent transmitral late diastolic velocity [A]) and evaluated the correlation of these parameters with selected clinical variables in type 2 diabetic patients. Using tissue Doppler echocardiography, 82 type 2 diabetic patients were evaluated, divided into two equal groups of E(m) < 7.5 cm/s or > or = 7.5 cm/s. Patients with E(m) < 7.5 cm/s had significantly lower E/A and E(m)/A(m), and higher E/E(m) values. Multilinear regression showed a negative correlation between E(m) and glycated haemoglobin (Hb(A1c)) and duration of diabetes, a negative correlation of E(m)/A(m) with age, duration of diabetes and Hb(A1c), and a positive correlation of E/E(m) with age, duration of diabetesand use of diuretics. The E/A ratio only correlated negatively with age. It is concluded that E(m) is a reliable parameter of diastolic function, and that the tissue Doppler parameters of diastolicfunction are associated with diabetes compensation and diabetes duration.
 
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