Accreditation valid until: 23. 9. 2030

Chairman of the Subject Area Board:

prof. MUDr. Jan LACZÓ, Ph.D.
Department of Neurology
Second Faculty of Medicine
Charles University and Motol University Hospital
V Úvalu 84
150 06  Prague 5
phone: +420 224 436 860
e-mail: @email


Contact person:
ThDr. Jitka Sýkorová, Ph.D.
Department for PhD Study
Second Faculty of Medicine
Charles University
V Úvalu 84
150 06  Prague 5
phone:+420 224 435 836
e-mail: @email


Members of the Subject Area Board

Characteristics of the study programme

The study programme is concerned with all aspects of the study and research of nerve tissue, both central and peripheral, in its physiologic state and in disease, in basic research and in clinical applied research. The study programme consists of the following parts: neuroanatomy, neurophysiology, neurogenetics, neuropathology, neurology, psychiatry, neurosurgery, neuropharmacology, neurorehabilitation and neuroimaging.

The goal of the study is that the student may obtain knowledge of the field of neurosciences as a whole, ability of independent scientific work, ability of independent research including of publication of its results in scientific/professional periodicals with a defined IF, all of that with the respect of nerve tissue and its physiology and pathophysiology, and clinical research.

Admission procedure requirement specific to the study programme

The conditions and course of the admission procedure for the part-time of study are the same as the conditions for the full-time form. 

We recommend to contact your potential supervisor in advance and consult the suitable form of preparation for the interview. Each study programme has its own specifics, so the supervisor can help you to prepare for the specialized entrance examination (the interview).

Topics of dissertation thesis

The SAB did not list any topics. The candidate chooses the preliminary topic individually and contacts a potential supervisor. He/she consults with him on the chosen topic and agrees on its more precise specification. In case of any ambiguity, we recommend that you also contact the chairman of the SAB. If necessary, he/she can recommend that he/she consult the topic with another specialist according to the focus of the intended project.

If the candidate does not know which topic/supervisor to choose, he/she will contact the chairman of the SAB, with whom he/she will consult on a suitable topic and a potential supervisor.

This choice is preliminary, the admissions board may, after consultation with the candidate, nominate another supervisor.

Supervisors of the study programme

Each supervisor must be approved by the SAB. The criteria for admitting new supervisors are determined by the SAB. If the proposed supervisor has not yet been approved by the SAB, this must be done no later than the enrollment of the applicant in the study (provided that the applicant is accepted). You can find a list of supervisors approved by the SAB here. After clicking, the supervisor's workplace and contact information will be displayed.

Requirements during the study

Study obligations for full-time and part-time form of study are the same. 

  • Quality ISP and its proper implementation (checked by the supervisor).
  • Completion of the course Advances in Neurosciences. This is a two-week full-day course, which is an overview of current neuroscience research. The course is taught by academic staff of the three Prague medical faculties of the Charles University and staff of the Czech Academy of Sciences and the National Institute of Mental Health. Tolerated absence is one and a half days.
  • Another course from the DSPB offer.

The SAB will now recognize the following courses in scientific work and biostatistics:

  • Course of basics of scientific work at the Czech Academy of Science (B90068)
  • Course of basics of scientific activities at the Second Faculty of Medicine CU (DS001)
  • Introduction to the practical methodology of scientific work at the Third Faculty of Medicine CU (CPGS005)
  • Biostatistics course for doctors and PhD students in biomedical fields at the First Faculty of Medicine CU (B90211)

Other courses are recognized by the SAB only based on a submitted application. It is recommended that the chosen course be related to the content of the study or the topic of the dissertation. 

  • English language examination (D0400003; Examination at the Department of Languages, Second Faculty of Medicine CU, State language examination or internationally recognized language examination, e.g. TOEFL, Cambridge Certificate) 
  • State doctoral examination (D0400001)

Active participation in scientific conferences, congresses and conventions (according to the supervisor's instructions or with his/her recommendation).

Acquisition of the basics of scientific work so that after graduation the student is capable of performing independent scientific work and publications of its results in internationally recognized journals.

Requirements for internships

In accordance with the Rector's Directive recommends an internship at a foreign institution for a duration of at least one month. However, part of the study abroad can be replaced in justified cases by another form of direct student participation in international cooperation, e.g. participation in a research project.

Listed courses

Advances in neurosciences (B90005)
Basics of scientific work at the Czech Academy of Science (B90068)
Course of basics of scientific activities at the Second Faculty of Medicine CU (DS001)
Introduction to the practical methodology of scientific work at the Third Faculty of Medicine CU (CPGS014)
Biostatistics course for doctors and PhD students in biomedical fields at the First Faculty of Medicine CU (B90211)

Requirements for the SDE

  • Completion of the course Advances in Neurosciences (B90005) and another course within the DSPB (compulsory is at least one according to the choice of the student and the supervisor)
  • Acceptance / publication of at least one article in a peer-reviewed journal from the RIV database, which, however, need not have an IF. If the student is a co-author, it must be an original article in a journal with a defined IF; if the student is the first author, it must be an article (original or review). Short messages, letters to the editor, etc. are not recognized for this purpose.

The dates of SDE for the current academic year can be found here

If, for serious reasons, the student is unable to attend the SDE at the scheduled time and is excused from this date by the dean, a replacement date is set for the student, which is usually the nearest date that follows this date. Assignment of another SDE term is not a right.

Examination topics for the SDE

1. Structure and function of the cell membrane

2. Membrane transport

3. Nerve cell excitability and ion channels

4. Membrane and action potential

5. Impulse conduction in nerve fibres

6. Glial cells and their functions

7. Structure and function of the synapses

8. Synaptic receptors

9. Overview of mediators

10. The role of acetylcholine at the neuromuscular junction and in the CNS

11. Catecholamine mediators, serotonin

12. Opioid peptides and their receptors

13. Neuropeptides and functions of the hypothalamus

14. Excitatory aminoacids as synaptic mediators

15. Glutamate receptors

16. GABA and glycine

17. Nitrogenoxide and its role in the CNS

18. G proteins and cyclic nucleotides in the CNS

19. Protein phosphorylation and regulation of the functions of the nervous system

20. Axonal transport

21. Development of the CNS and neural crest – the role of genes

22. Neural plasticity and regulation

23. The effect of ageing on the nervous system

24. Cerebrospinal fluid and blood-brain-barrier

25. Blood circulation in the brain and energy metabolism of the brain

26. Extracellular space of the CNS

27. Structure and functions of the peripheral nervous system

28. Structure and functions of the spinal cord

29. Structure and functions of the vegetative nervous system

30. Sensory functions, overview, general characteristics of receptors

31. Somatosensory system

32. Pain

33. Eye – receptors and nerve cells

34. Anatomy and physiology of the central visual system

35. Hearing – the inner ear and the central auditory system

36. Vestibular system

37. Chronobiology

38. The motor system of the brain

39. The control of movement – the role of the basal ganglia and the cerebellum

40. The brain and emotions – the role of the limbic system

41. The brain cortex and the integrative functions of the CNS

42. The role of the thalamus

43. The electric activity of the brain – electroencephalography (EEG)

44. The electric activity of the brain – slow (evoked) potentials

45. The electric activity of the brain – evoked potentials

46. Functional brain imaging techniques

47. Recording of neuronal and glial activity – extracellular and intracellular recordings

48. Sleep and wakefulness – their regulation and relation to basic physiological functions

49. Ion-selective microelectrodes, the principles of their function and use

50. Brain sections, the principle of the method and its use

51. Basics of brain anatomy

52. Disorders of speech and gnosia

53. Neurophysiology of learning and memory

54. Ischaemia and hypoxia of the CNS

55. Epilepsy

56. Disorders of the basal ganglia and their mediators

57. Alzheimer’s disease

58. The biochemical aspects of mental disorders

59. Behavioural models of learning and memory

60. Neuroendocrinology

61. Disorders of synaptic transmission at the neuromuscular junction

62. The effects of toxic substances on the nervous system

63. Demyelinating diseases

64. Psychiatric diseases – basic characteristics

65. Disorders of sleep and wakefulness

66. Stereotaxy of the CNS, Gamma Knife radiosurgery

Recommended literature

Kalat JW. Biological Psychology. Belmont, Calif: Wadsworth, Cengage Learning, 2009.
Snell RS. Clinical Neuroanatomy for Medical Students. 5th Edition. Lippincott, Williams and Wilkins, 2001.
Brodal P. The Central Nervous System. 3rd Edition. Oxford University Press, 2004.
Purves D. et al.: Neuroscience. 2nd Edition, Sinauer Assoc. Sunderland, 2001.
Rosenzweig MR et al. Biological Psychology. 3rd Edition, Sinauer Assoc. Sunderland, 2002.
Cooper JR et al. The Biochemical Basis of Neuropharmacology. 8th Edition, Oxford University Press, 2003.
Balazs B, Bridges RJ, and Cotman CW. Excitatory Amino Acid Transmission in Health and Disease. Oxford University Press, 2006.

Publication activity requirements

Preparation and implementation of research that leads to the acquisition of results, which are subsequently published and presented in the dissertation thesis. Submission of at least three original works accepted for publication or already published in journals with a defined impact factor, the cumulative value of which exceeds 1,5. The student is the first author of at least one of these publications and the impact factor of the journal of this work exceeds 1,0.

Defence requirements

  • SDE
  • At least three accepted / published original publications in journals with IF (total sum is higher than 1,5), of which at least one publication with first authorship in a journal with IF higher than 1,0. 
  • The SAB requires a Summary of the Dissertation.

The dates of the defences for the current academic year can be found here.

Profile of a graduate of the study programme

The study programme is designed for the study of the structure, functions and disorders of the nervous system. The programme covers, in particular, neuroanatomy, neurophysiology, neurogenetics, neuropathology and neuropathophysiology, methods used in those disciplines, essential clinical knowledge of neurology, neurosurgery and psychiatry as well as of the diagnostic methods used in those disciplines. A graduate has the basic knowledge of all the above parts of the discipline, is capable of independent scientific work, and well-versed in the current state of knowledge in the field of his/her dissertation. A graduate is mentioned as an author/ess in the basic reference databases of his/her field of study.

Information about graduate employment 

Researchers in academic institutions and commercial research. Teachers in higher education. Doctors in senior positions (after some medical experience).

Created: 22. 2. 2013 / Modified: 29. 3. 2022 / Responsible person: ThDr. Jitka Sýkorová, Ph.D.