Cell Biology and Pathology

Accreditation valid until: 27. 11. 2029

Chairman of the Subject Area Board:

doc. MUDr. Tomáš KUČERA, Ph.D.

Institute of Histology and
Embryology
First Faculty of Medicine
Charles University
Albertov 4
128 01  Prague 2
phone: +420 224 968 125
e-mail:
@email

 

Members of the Subject Area Board

Characteristics of the study programme

Cell Biology and Pathology is a field of biomedical science concerned with build-up and functional characteristics of particular cells and their interaction in construction of tissues and organs. The content matter of the study is, above all, the cell itself at various levels of its functional organization, also concerning interconnection of structural-functional levels that maintain the cell as the basic structural and functional unit of multicellular organism including the human.

The goal of the studies is training the student for independent scientific research work aimed at understanding of dynamics, mutual connections and functional-structural characteristics of cells and tissues under normal – physiological conditions and in pathologic processes as well as in their modelling

Admission procedure requirement specific to the study programme

The conditions and course of the admission procedure for the part-time of study are the same as the conditions for the full-time form. 

We recommend to contact your potential supervisor in advance and consult the suitable form of preparation for the interview. Each study programme has its own specifics, so the supervisor can help you to prepare for the specialized entrance examination (the interview).

Topics of dissertation thesis

The SAB did not list any topics. The candidate chooses the preliminary topic individually and contacts a potential supervisor. He/she consults with him on the chosen topic and agrees on its more precise specification. In case of any ambiguity, we recommend that you also contact the chairman of the SAB. If necessary, he/she can recommend that he/she consult the topic with another specialist according to the focus of the intended project.

If the candidate does not know which topic/supervisor to choose, he/she will contact the chairman of the SAB, with whom he/she will consult on a suitable topic and a potential supervisor.

This choice is preliminary, the admissions board may, after consultation with the candidate, nominate another supervisor.

Supervisors of the study programme

Each supervisor must be approved by the SAB. The criteria for admitting new supervisors are determined by the SAB. If the proposed supervisor has not yet been approved by the SAB, this must be done no later than the enrollment of the applicant in the study (provided that the applicant is accepted). You can find a list of supervisors approved by the SAB here. After clicking, the supervisor's workplace and contact information will be displayed.

Requirements during the study

Study obligations for full-time and part-time form of study are the same. 

  • After admission, compilation of an ISP, which must be approved by the supervisor and guarantor of the programme.
  • After each academic year passed, evaluation of the ISP with the supervisor, and forwarding this ISP within the deadlines so that is will be further judged by the SAB and approved by the guarantor of the programme.
  • Passing the following courses:
  1. Progress in cell biology – a compulsory course – organized by the SAB for Cell Biology and Pathology and guarantor of the programme.
  2. Progress in molecular biology and genetics – a compulsory course – organized by the Institute of Molecular Genetics of the Czech Academy of Sciences.

Recommended are any other possible courses organized by the SAB with a bias close to the student’s programme. It is appropriate if courses organized by the CU or the Czech Academy of Sciences are included where the student can obtain knowledge and skills necessary for successful presentation of the results, work with professional and scientific literature and scientific data bases as well as for gaining the grants.

  • Language examination in English (examination at the Institute for Languages of Second Faculty of Medicine, State language examination or an internationally recognized examination, e.g. TOEFL, Cambridge Certificate). Other world languages are optional.
  • SDE

Requirements for internships

At least one one-month or longer placement abroad is presumed. This can be replaced by participation in an international grant project or another form of direct participation in international co-operation, at the supervisors scope and discretion.

Listed courses

B90019 Pokroky v biologii buňky
B90041 Pokroky v molekulární biologii a genetice

 

Requirements for the SDE

  • The examination must be taken before submission of the dissertation thesis and after fulfilling the substantial portion of ISP. At least one publication on the topic of the disseration thesis with the student as an author is recommended.
  • Passing the two compulsory courses: Progress in cell biology and Progress in molecular biology and genetics.
  • Language examination in English. The SAB recommends and internationally recognized type of examination (TOEFL, Cambridge), however study rules of particular faculties allow to take the language exam at the faculty’s institute of languages and admit recognition of the State language examination in English.
The course of the SDE
 

In the first part of the SDE, the student will present a lecture in approximately 15 minutes about the results of his/her own scientific work achieved during the previous studies. Then members of the board will ask the student to answer some questions pertaining to the results achieved. In the second part, the student shall answer three questions drawn at random from the published list of questions, which cover the following topic areas.

Examination topics for the SDE

A. Molecular and Cellular Biology
Basic chemical composition of a cell and the cell metabolism
Genome and gene expression
DNA – replication, transcription; RNA – types, splicing
Biological functions of proteins – enzymes
Cell – types (eukaryotes, prokaryotes, vegetable vs. animal cell) and basic organization
Structure and function of biological membrane and cell organelles
Cell nucleus – structure, function, pathology
Cellular transport
Cytoskeleton – components and their functions
Cell cycle and cell division, cell death
Stem cells and cell differentiation
Basic types of tissues
Intercellular communication, cell adhesion and motion
Structure and function of intercellular matrix

B. Basic methods for investigation of cells and tissues
Microscoping technique – optical and electron microscope, advanced microscoping methods
Methods in histochemistry; immunocytochemistry and histochemistry
Basic molecular genetic methods – PCR, sequencing, in situ hybridization
Survey of biochemical methods in cell biology – blotting techniques
Model organisms, tissue and cell cultures

C. General pathology of cells and tissues
Regressive changes to cells and tissues
Inflammation and survey of defensive response of the organism
Interactions of cells with pathogens
Regeneration and reparation of tissues, metaplasia
Tumour transformation of the cell, major types of tumours
Physiological and pathological growth of vessels
Cellular biological bases of cardiovascular and metabolic conditions

Recommended literature
Alberts B. et al.: Molecular Biology of the Cell (6th edition), 2014, Garland Science
Alberts B. et al.: Essential Cell Biology (4th edition), 2016, Garland Science
Pollard T. D., Earnshaw W. C., Lippincott - Schwartz J.: Cell Biology, (3rd edition), 2016, Elsevier
Lodish H. et al.: Molecular Cell Biology (8th edition), 2016, W. H. Freeman and Co.
Weinberg R. A.: The Biology of Cancer (2nd edition), 2013, Garland Science
Sambrook J. et al: Molecular cloning: A laboratory manual/Joseph Sambrook,
David W. Russel, (3rd edition) Cold Spring Harbor, NY: Cold Spring Harbor Laboratory, 2001.

Publication activity requirements

Being the first author of a publication. Participation in a research grant project.

Defence requirements
 
  • Fulfilling all the above mentioned study obligations incl. passing the SDE.
  • Being the author (co-author) of at least two original scientific papers on the topic of the dissertation thesis, published or accepted for publication in an internationally respected journal with an impact factor (Web of Science), the student must be the first author of at least on of the publications.
  • The subject area board requires a Summary of the Dissertation.

Profile of a graduate of the study programme

The graduate is familiar with basic cell biology and pathology, special characteristics of various cell and tissue types both in physiological situation as well as in disease. The graduate is acquainted with current research topics and experimental approaches especially in the following areas: cellular basis of cancerogenesis, tissue and cellular processes in inflammation, changes of cells and tissues during metabolic diseases; tissue repair and regeneration; wound healing; cell and tissue replacement; stem cell biology. 

Information about graduate employment 

Graduates of the study programme will be employed as researchers at theoretical institutes (anatomy, pathology, forensic medicine, histology) of medical and natural science faculties, institutes of the Czech Academy of Sciences, biomedical research centres, scientific research departments of clinical workplaces and possibly as employees of clinical laboratories. They will also be employed as scientifically qualified university teachers. Last but not least, they will be able to apply their theoretical knowledge and skills in the commercial sector (biotechnology, pharmacy, clinical and laboratory diagnostics, etc.).

 

Created: 26. 10. 2021 / Modified: 14. 3. 2022 / Responsible person: ThDr. Jitka Sýkorová, Ph.D.