Veselka J, Hájek P, Malý M, Zemánek D, Adlová R, Tomašov P, Martinkovičová L, Tesař D, Červinka P. Arch Med Sci 2011; 7, 1: 67–72, IF: 1,199
Abstract:
Background: Peri-procedural myocardial infarction (PMI) is a frequent and prognostically important complication of percutaneous coronary intervention (PCI). This study was designed to determine the predictors of PMI in patients pretreated with statins. Methods: A total of 418 stable angina pectoris patients taking statins and aspirin were included. All the patients underwent the PCI. Serum concentration of creatine kinase (CK-MB mass) and troponin I (TnI) were measured prior to and then within 16 to 24 hours after PCI. The incidence of PMI was assessed using the established criteria (≥3times the ULN). Results: Four hundred and eighteen stable patients (63 ± 10 years, 68% males) were treated by the PCI. The technical success rate of PCI was 99%. The incidence of PMI based on CK-MB mass or TnI release was 12% (PMI group). There were no significant differences in baseline clinical and procedural characteristics between PMI vs non-PMI group except for the incidence of the balloon inflation time (40 ± 44 s vs 26 ± 27 s; p = 0.02) and proportion of treated lesions type C (42% vs 28%; p = 0.03). By multivariate analysis, the independent predictors of PMI were balloon inflation time (OR = 1.01; 95% CI = 1.001–1.020; p = 0.02) and pre-procedural level of C-reactive protein (OR = 1.38; 95% CI = 1.059–1.808; p = 0.02). Conclusion: The above mentioned results suggest that C-reactive protein and balloon ischemic time are independent predictors of PMI in stable angina pretreated with statins.
