Charles University in Prague - 2nd Faculty of Medicine, V Úvalu 84, Praha 5, 150 06
Urinary transforming growth factor-β1 in children with obstructive uropathy.
Zieg J, Blahova K, Seeman T, Bronsky J, Dvorakova H, Pechova M, Janda J, Matousovic K. Nephrology (Carlton). 2011 Aug;16(6):595-8. IF: 1.172
Department of Paediatrics
AIM: Obstructive uropathies (OU) in childhood constitute one of the major causes of chronic renal insufficiency. Transforming growth factor-β1 (TGF-β1) is considered to be the major fibrogenicgrowth factor. The aim of the present study was to investigate urinary TGF-β1 levels in children with obstructive and non-obstructive uropathies (NOU). METHODS: This study involved 19 children with OU, 11 children with non-obstructive hydronephrosis and 21 healthy children. Urinary TGF-β1, proteinuria, microalbuminuria and urinary β1-microglobulin were measured, and renal function was assesed. The results were statistically analyzed. RESULTS: Mean urinary TGF-β1 concentrations in patients with OU were significantly higher than those with NOU (4.14 ± 0.67 creatinine vs 1.80 ± 0.24 pg/mmol creatinine, P < 0.05) and healthy controls (1.66 ± 0.28 pg/mmol creatinine, P < 0.05). Positive correlations of urinary TGF-β1 concentrations with proteinuria (r = 0.87, P < 0.0001) and urinary β1-microglobulin (r = 0.82, P = 0.0002) were found in patients with OU. CONCLUSION: Children with OU have higher urinary TGF-β1 than children with NOU. Urinary TGF-β1 may be a useful non-invasive tool for the differential diagnosis between OU and NOU inchildren. A positive correlation of TGF-β1 with markers of renal tissue damage in patients with OU was found.
Submitted by , Department of Immunology, for posting on the web 10. 2. 2012.